DYNLL2 Gene Summary [Human]
Predicted to enable dynein intermediate chain binding activity and dynein light intermediate chain binding activity. Predicted to be involved in cilium assembly. Located in 9+0 non-motile cilium and centrosome. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DYNLL2 |
| Official Name | dynein light chain LC8-type 2 [Source:HGNC Symbol;Acc:HGNC:24596] |
| Ensembl ID | ENSG00000264364 |
| Bio databases IDs | |
| Aliases | dynein light chain LC8-type 2, radial spoke 22 homolog (Chlamydomonas) |
| Synonyms | 1700064A15Rik, 6720463E02Rik, Dlc2, DLC8, DLC8b, DNCL1B, dynein light chain LC8-type 2, LOC105247666, RSPH22 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DYNLL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PLN03058
- binding protein
- Dynein light chain type 1
- dynein light chain (DLC)-like domain superfamily
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the DYNLL2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- ciliary tip
- non-motile cilium
- cytoskeleton
- cilia
- postsynaptic region
- Plasma Membrane
- centrosome
- cytosol
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DYNLL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule-based process
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasmic dynein complex
- cytoskeleton
- membrane
- myosin V complex
- cilium
- cytosol
- plasma membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- dynein intermediate chain binding