IFT27 Gene Summary [Human]
This gene encodes a GTP-binding protein that is a core component of the intraflagellar transport complex B. Characterization of the similar Chlamydomonas protein indicates a function in cell cycle control. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Details
| Type | Protein Coding |
| Official Symbol | IFT27 |
| Official Name | intraflagellar transport 27 [Source:HGNC Symbol;Acc:HGNC:18626] |
| Ensembl ID | ENSG00000100360 |
| Bio databases IDs | |
| Aliases | intraflagellar transport 27 |
| Synonyms | 2600013G09RIK, BBS19, CFAP156, FAP156, intraflagellar transport 27, RABL4, RAB, member of RAS ONCOGENE family-LIKE 4, RAYL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFT27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- small GTP-binding protein domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- Rab subfamily of small GTPases
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- motile cilia
- ciliary tip
- Cytoplasm
- cilia
- Nucleus
- centrosome
- sperm midpiece
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFT27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear receptor stereocilium organization
- vesicle-mediated transport
- cilium morphogenesis
- intraflagellar transport
- cochlea development
- kidney development
- spermatogenesis
- smoothened signaling pathway
- intracellular protein transport
- intraflagellar anterograde transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- motile cilium
- sperm midpiece
- cytoplasm
- cilium
- sperm principal piece
- intraflagellar transport particle B
- Golgi apparatus
- Golgi membrane
- sperm flagellum
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity