Ift27 Gene Summary [Rat]
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including intraciliary transport; smoothened signaling pathway; and spermatogenesis. Predicted to act upstream of or within cochlea development and inner ear receptor cell stereocilium organization. Predicted to be located in centrosome; nucleus; and sperm flagellum. Predicted to be part of intraciliary transport particle B. Predicted to be active in Golgi membrane and cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 19. Orthologous to human IFT27 (intraflagellar transport 27). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ift27 |
| Official Name | intraflagellar transport 27 [Source:RGD Symbol;Acc:1308703] |
| Ensembl ID | ENSRNOG00000006440 |
| Bio databases IDs | |
| Aliases | intraflagellar transport 27 |
| Synonyms | 2600013G09RIK, BBS19, CFAP156, FAP156, intraflagellar transport 27, RABL4, RAB, member of RAS ONCOGENE family-LIKE 4, RAYL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ift27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- small GTP-binding protein domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- Rab subfamily of small GTPases
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- motile cilia
- ciliary tip
- Cytoplasm
- cilia
- Nucleus
- centrosome
- sperm midpiece
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ift27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear receptor stereocilium organization
- vesicle-mediated transport
- cilium morphogenesis
- intraflagellar transport
- cochlea development
- kidney development
- spermatogenesis
- smoothened signaling pathway
- intracellular protein transport
- intraflagellar anterograde transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- motile cilium
- sperm midpiece
- cytoplasm
- cilium
- sperm principal piece
- intraflagellar transport particle B
- Golgi apparatus
- Golgi membrane
- sperm flagellum
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity