PIGH Gene Summary [Human]
This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PIGH |
| Official Name | phosphatidylinositol glycan anchor biosynthesis class H [Source:HGNC Symbol;Acc:HGNC:8964] |
| Ensembl ID | ENSG00000100564 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol glycan anchor biosynthesis class H, phosphatidylinositol N-acetylglucosaminyltransferase subunit |
| Synonyms | 2210416H01Rik, A930028P05Rik, GPI-H, phosphatidylinositol glycan anchor biosynthesis class H, phosphatidylinositol glycan anchor biosynthesis, class H |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIGH often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GPI-GlcNAc transferase complex, PIG-H component
- phosphatidylinositol N-acetylglucosaminyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIGH gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- GPI anchor biosynthetic process
- protein modification process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- catalytic activity