RINT1 Gene Summary [Human]
This gene encodes a protein first identified for its ability to interact with the RAD50 double strand break repair protein, with the resulting interaction implicated in the regulation of cell cycle progression and telomere length. The encoded protein may also play a role in trafficking of cellular cargo from the endosome to the trans-Golgi network. Mutations in this gene may be associated with breast cancer in human patients. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | RINT1 |
| Official Name | RAD50 interactor 1 [Source:HGNC Symbol;Acc:HGNC:21876] |
| Ensembl ID | ENSG00000135249 |
| Bio databases IDs | |
| Aliases | RAD50 interactor 1 |
| Synonyms | 1500019C06Rik, 2810450M21Rik, FLJ11785, ILFS3, RAD50 interactor 1, RGD1560433 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RINT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- RINT-1 / TIP-1 family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- benign neoplasia
regulated by
- dextran sulfate
- CSF2
- myoblasts
regulates
- reactive oxygen species
- diacylglycerol
- phosphatidylserine
- adenosine triphosphate
- triacylglycerol
- lysophosphatidylserine
- phosphatidylethanolamine
- lysophosphatidylcholine
- lysophosphatidylethanolamine
- phosphatidylcholine
role in cell
- fragmentation in
- formation
- cell death
- fragmentation
- depolarization
- amplification
- number
- depolarization in
- dynamics
- fission in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RINT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- ER to Golgi vesicle-mediated transport
- regulation of ER to Golgi vesicle-mediated transport
- retrograde vesicle-mediated transport, Golgi to ER
- protein transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- Dsl1p complex
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding