SEC63 Gene Summary [Human]
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SEC63 |
| Official Name | SEC63 homolog, protein translocation regulator [Source:HGNC Symbol;Acc:HGNC:21082] |
| Ensembl ID | ENSG00000025796 |
| Bio databases IDs | |
| Aliases | SEC63 homolog, protein translocation regulator |
| Synonyms | 5730478J10Rik, DNAJC23, ERdj2, PCLD2, PRO2507, SEC63 homolog, protein translocation regulator, SEC63L |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SEC63 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaJ domain
- Sec63 Brl domain
- DnaJ
- signaling receptor activity
- DnaJ molecular chaperone homology domain
- Domain of unknown function in Sec63p, Brr2p and other proteins
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- polycystic liver disease type 2
- hepatocellular carcinoma
- organismal death
- autosomal dominant polycystic liver disease
- colorectal carcinomagenesis
- polycystic liver disease type 2 without kidney cysts
- polycystic liver disease 1
- colorectal carcinoma
role in cell
- expression in
- dipeptide repeat protein sensitivity
- endoplasmic reticulum-associated degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SEC63 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SRP-dependent cotranslational protein targeting to membrane
- liver development
- posttranslational protein targeting to membrane, translocation
- protein targeting to membrane
- posttranslational protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- Sec62/Sec63 complex
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- protein transmembrane transporter activity
- signaling receptor activity