TYW1 Gene Summary [Human]
Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Details
| Type | Processed Transcript |
| Official Symbol | TYW1 |
| Official Name | tRNA-yW synthesizing protein 1 homolog [Source:HGNC Symbol;Acc:HGNC:25598] |
| Ensembl ID | ENSG00000198874 |
| Bio databases IDs | |
| Aliases | tRNA-yW synthesizing protein 1 homolog, tRNA-yW synthesizing protein 1 homolog A (S. cerevisiae) |
| Synonyms | FLJ10900, LOC103690026, RGD1310420, RSAFD1, tRNA-yW synthesizing protein 1 homolog, TYW1A, YPL207W |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TYW1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Radical_SAM
- Radical SAM superfamily
- flavodoxin
- wyosine biosynthesis protein TYW1
- Wyosine base formation
- NADPH-dependent FMN reductase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TYW1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wybutosine biosynthetic process
Molecular Function
What the gene product does at the molecular level
- FMN binding
- metal ion binding
- 4 iron, 4 sulfur cluster binding