IFITM1 Gene Summary [Human]
Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 that belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]
Details
| Type | Protein Coding |
| Official Symbol | IFITM1 |
| Official Name | interferon induced transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:5412] |
| Ensembl ID | ENSG00000185885 |
| Bio databases IDs | |
| Aliases | interferon induced transmembrane protein 1, interferon-induced transmembrane protein 1, dispanin subfamily A member 2a |
| Synonyms | 9-27, CD225, DSPA2a, HUM927A, IFI17, IFI27SEP, IFIM1, IFM1 9-27, IFN9-27, interferon induced transmembrane protein 1, LEU13 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFITM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Interferon-induced transmembrane protein
- protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the IFITM1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- hepatocellular carcinoma
- epithelial cancer
- liver cancer
- delayed hypersensitive reaction
- COVID-19
- systemic lupus erythematosus
- myelodysplastic syndrome
- colon cancer
role in cell
- growth
- expression in
- differentiation
- migration
- proliferation
- formation
- fusion
- invasion by
- replication in
- viral entry in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Golgi Apparatus
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFITM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to interferon-gamma
- negative regulation of cell proliferation
- cell surface receptor signaling pathway
- response to virus
- positive regulation of osteoblast differentiation
- type I interferon-mediated signaling pathway
- negative regulation of viral entry into host cell
- ossification
- defense response to virus
- response to interferon-alpha
- response to interferon-beta
- negative regulation of viral genome replication
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- membrane
- macromolecular complex
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding