AKAP11
AKAP11 Gene Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | AKAP11 |
| Official Name | A-kinase anchoring protein 11 [Source:HGNC Symbol;Acc:HGNC:369] |
| Ensembl ID | ENSG00000023516 |
| Bio databases IDs | |
| Aliases | A-kinase anchoring protein 11, AKAP 220, A-kinase anchoring protein, 220kDa, protein kinase A anchoring protein 11, protein phosphatase 1, regulatory subunit 44 |
| Synonyms | 6330501D17,6330501D17Rik,Akap,AKAP220,A-kinase anchoring protein 11,A kinase anchor protein 11,Gm80,mKIAA0629,PPP1R44,PRKA11 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GSK-3beta binding domain
- protein kinase A binding
- protein phosphatase 1 binding
- protein kinase binding
- kinase regulator
- PP1 binding domain
- R2 binding domain
- protein binding
Pathways
Biological processes and signaling networks where the AKAP11 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- GSK3B
- VAPA
- LITAF
- Gsk3b
- CUL3
- PPP1CC
- CREB3L3
- TSPYL1
- PPP1CA
- NUAK1
disease
- schizophrenia
- bipolar disorder
- amyotrophic lateral sclerosis
- chronic lymphocytic leukemia
regulated by
- GSKIP
- MIRN1
- CHI3L1
- ATG7
- AKAP11
- GRIN2A
regulates
- adenosine triphosphate
- GSK3B
- RHOA
- AKAP11
- PRKAR1A
- MT-CO2
- MYBPC2
- CREB
- PKA
- NDUFS4
role in cell
- cell death
- migration
- production in
- formation
- formation in
- accumulation in
- elongation
- respiration in
- disruption
- elongation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cell cortex
- Nucleus
- Plasma Membrane
- centrosome
- cytosol
- nucleoli
- peroxisomes
- cortical actin filaments
- cell membrane leading edge
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the AKAP11 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cortical actin cytoskeleton organization
- renal water homeostasis
- protein localization in endosome
- protein localization
- intracellular signal transduction
CELLULAR COMPONENT
Where in the cell the gene product is active
- centrosome
- cytoplasm
- cytosol
- nucleolus
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- protein kinase A regulatory subunit binding
- protein phosphatase 1 binding
- protein kinase A binding