MZB1 Gene Summary [Human]
Involved in positive regulation of cell population proliferation. Located in cytoplasm and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MZB1 |
| Official Name | marginal zone B and B1 cell specific protein [Source:HGNC Symbol;Acc:HGNC:30125] |
| Ensembl ID | ENSG00000170476 |
| Bio databases IDs | |
| Aliases | marginal zone B and B1 cell specific protein, plasma cell-induced ER protein 1, proapoptotic caspase adaptor protein, mesenteric oestrogen-dependent adipose gene- 7 |
| Synonyms | 2010001M09Rik, marginal zone B and B1 cell-specific protein, marginal zone B and B1 cell-specific protein 1, MEDA-7, PACAP, pERp1, PROAPOPTOTIC CASPASE 2/9 binding, RGD1310251 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MZB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- TLR4 regulator and MIR-interacting MSAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- colitis
- hyperinsulinism
- idiopathic pulmonary fibrosis
- insulin-dependent diabetes mellitus
- systemic sclerosis
role in cell
- cell death
- apoptosis
- expression in
- proliferation
- differentiation
- number
- coupling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MZB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of B cell proliferation
- positive regulation of cell proliferation
- apoptotic process
- positive regulation of immunoglobulin production
- regulation of insulin receptor signaling pathway
- regulation of cell proliferation
- integrin activation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- endoplasmic reticulum chaperone complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding