NTSR1 Gene Summary [Human]
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NTSR1 |
| Official Name | neurotensin receptor 1 [Source:HGNC Symbol;Acc:HGNC:8039] |
| Ensembl ID | ENSG00000101188 |
| Bio databases IDs | |
| Aliases | neurotensin receptor 1 |
| Synonyms | Neurotensin Receptor, neurotensin receptor 1, NT-1R, NTR, NTR-1, Nts1, NTSR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NTSR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled neurotensin receptor
- binding protein
- neuropeptide receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the NTSR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- leiomyomatosis
- lung cancer
- hypoperistalsis
- pancreatic cancer
- small cell lung cancer
- COVID-19
- hypothermia
- ductal breast carcinoma
- ductal breast cancer
regulated by
- dexamethasone
- beta-estradiol
- acetate
- contulakin-G
- Jmv 449
- GSK3B
- decitabine
- verapamil
- nonglycosylate Thr10 contulakin-G
- SLCO4A1-AS1
role in cell
- expression in
- differentiation
- proliferation
- apoptosis
- depolarization
- migration
- invasion by
- remodeling
- remodeling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- Nucleus
- endosomes
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytoplasmic face of plasma membrane
- nuclear envelope
- dendritic spines
- neurites
- synapse
- membrane rafts
- perikaryon
- axons
- dendrites
- axon terminals
- dendritic shafts
- dendritic branches
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NTSR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of arachidonic acid secretion
- G-protein coupled receptor signaling pathway
- positive regulation of gamma-aminobutyric acid secretion
- negative regulation of systemic arterial blood pressure
- synaptic transmission
- adult locomotory behavior
- regulation of respiratory gaseous exchange
- negative regulation of release of sequestered calcium ion into cytosol
- positive regulation of release of sequestered calcium ion into cytosol
- regulation of membrane depolarization
- learning
- positive regulation of inhibitory postsynaptic membrane potential
- positive regulation of inositol phosphate biosynthetic process
- neuropeptide signaling pathway
- negative regulation of apoptotic process
- positive regulation of gene expression
- temperature homeostasis
- positive regulation of apoptotic process
- inositol phosphate catabolic process
- response to lipid
- D-aspartate import
- detection of temperature stimulus involved in sensory perception of pain
- positive regulation of glutamate secretion
Cellular Component
Where in the cell the gene product is active
- symmetric synapse
- terminal button
- dendritic shaft
- dendritic spine
- membrane raft
- Golgi apparatus
- endoplasmic reticulum
- perikaryon
- plasma membrane
- cell surface
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- identical protein binding
- protein binding
- G-protein coupled neurotensin receptor activity