KLRD1 Gene Summary [Human]
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
Details
| Type | Protein Coding |
| Official Symbol | KLRD1 |
| Official Name | killer cell lectin like receptor D1 [Source:HGNC Symbol;Acc:HGNC:6378] |
| Ensembl ID | ENSG00000134539 |
| Bio databases IDs | |
| Aliases | killer cell lectin like receptor D1 |
| Synonyms | CD94, killer cell lectin like receptor D1, NKG2B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLRD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- binding protein
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- MHC protein binding
- Lectin C-type domain
- antigen binding
- protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the KLRD1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- early-onset preeclampsia
- septic shock
- Tourette syndrome
- chronic natural killer lymphoproliferative disorder
- idiopathic scoliosis
- idiopathic pulmonary fibrosis
- aggressive NK-cell leukemia
role in cell
- expression in
- cell death
- activation
- cytotoxicity
- recognition
- cytolysis
- stimulation
- lysis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLRD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of natural killer cell activation
- natural killer cell mediated immunity
- adaptive immune response
- negative regulation of T cell mediated cytotoxicity
- cell surface receptor signaling pathway
- negative regulation of natural killer cell mediated cytotoxicity
- positive regulation of natural killer cell mediated cytotoxicity
- stimulatory C-type lectin receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- MHC class I protein complex binding
- transmembrane signaling receptor activity
- protein binding
- MHC class Ib protein binding, via antigen binding groove
- carbohydrate binding