CRNKL1 Gene Summary [Human]
The crooked neck (crn) gene of Drosophila is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. A protein encoded by this human locus has been found to localize to pre-mRNA splicing complexes in the nucleus and is necessary for pre-mRNA splicing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | CRNKL1 |
| Official Name | crooked neck pre-mRNA splicing factor 1 [Source:HGNC Symbol;Acc:HGNC:15762] |
| Ensembl ID | ENSG00000101343 |
| Bio databases IDs | |
| Aliases | crooked neck pre-mRNA splicing factor 1, SYF3 pre-mRNA-splicing factor |
| Synonyms | 1200013P10Rik, 5730590A01RIK, CLF, Clf1, CRN, crooked neck pre-mRNA splicing factor 1, HCRN, LOC100360434, LOC102548514, MSTP021, SYF3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CRNKL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HAT (Half-A-TPR) repeats
- HAT (Half-A-TPR) repeat
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CRNKL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spliceosomal complex assembly
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- post-mRNA release spliceosomal complex
- nuclear speck
- spliceosomal complex
- U2-type catalytic step 2 spliceosome
- Prp19 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding