Crnkl1 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal complex assembly. Predicted to be located in nucleus. Predicted to be part of Prp19 complex; U2-type catalytic step 2 spliceosome; and post-mRNA release spliceosomal complex. Is expressed in several structures, including central nervous system and sensory organ. Human ortholog(s) of this gene implicated in basal cell carcinoma. Orthologous to human CRNKL1 (crooked neck pre-mRNA splicing factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crnkl1 |
| Official Name | crooked neck pre-mRNA splicing factor 1 [Source:MGI Symbol;Acc:MGI:1914127] |
| Ensembl ID | ENSMUSG00000001767 |
| Bio databases IDs | |
| Aliases | crooked neck pre-mRNA splicing factor 1 |
| Synonyms | 1200013P10Rik, 5730590A01RIK, CLF, Clf1, CRN, crooked neck pre-mRNA splicing factor 1, HCRN, LOC100360434, LOC102548514, MSTP021, SYF3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crnkl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HAT (Half-A-TPR) repeats
- HAT (Half-A-TPR) repeat
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- spliceosomes
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crnkl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spliceosomal complex assembly
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- post-mRNA release spliceosomal complex
- nuclear speck
- spliceosomal complex
- U2-type catalytic step 2 spliceosome
- Prp19 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding