RNMT Gene Summary [Human]
Enables RNA binding activity and mRNA (guanine-N7-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in fibrillar center and nucleoplasm. Part of mRNA cap binding activity complex; mRNA cap methyltransferase complex; and receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RNMT |
| Official Name | RNA guanine-7 methyltransferase [Source:HGNC Symbol;Acc:HGNC:10075] |
| Ensembl ID | ENSG00000101654 |
| Bio databases IDs | |
| Aliases | RNA guanine-7 methyltransferase, mRNA cap guanine-N7 methyltransferase |
| Synonyms | 2610002P10Rik, cm1p, CMT1, CMT1c, hCMT1, hMet, MET, mKIAA0398, MT, N7-MTase, RG7MT1, RNA (guanine-7-) methyltransferase, RNA guanine-7 methyltransferase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNMT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA (guanine-N7-)-methyltransferase
- importin alpha binding domain
- enzyme
- protein binding
- AdoMet_MTases
- methyltransferase domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- leukemia
- acute myeloid leukemia
- neoplastic cell transformation
- T-cell/histiocyte rich large B-cell lymphoma
- myelodysplastic syndrome
- high-grade B-cell lymphoma
- refractory diffuse large B-cell lymphoma
- grade 3b follicular lymphoma
- non-myeloproliferative chronic myelomonocytic leukemia
role in cell
- proliferation
- expression in
- cell viability
- apoptosis
- survival
- organismal death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNMT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA capping
Cellular Component
Where in the cell the gene product is active
- nucleus
- receptor complex
- fibrillar center
- nucleoplasm
- mRNA cap methyltransferase complex
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA (guanine-N7-)-methyltransferase activity