NXT2 Gene Summary [Human]
The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]
Details
| Type | Protein Coding |
| Official Symbol | NXT2 |
| Official Name | nuclear transport factor 2 like export factor 2 [Source:HGNC Symbol;Acc:HGNC:18151] |
| Ensembl ID | ENSG00000101888 |
| Bio databases IDs | |
| Aliases | nuclear transport factor 2 like export factor 2 |
| Synonyms | 6330587F24RIK, DC9, nuclear transport factor 2-like export factor 2, P15-2, p15-2a, RGD1560204 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NXT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- NTF2_like
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
- nuclear rim
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NXT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- protein transport
- poly(A)+ mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- nuclear RNA export factor complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding