RGS8 Gene Summary [Human]

This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
RGS8
Official Name
regulator of G protein signaling 8 [Source:HGNC Symbol;Acc:HGNC:16810]
Ensembl ID
ENSG00000135824
Bio databases IDs NCBI: 85397 Ensembl: ENSG00000135824
Aliases regulator of G protein signaling 8
Synonyms 6530413N01RIK, regulator of G-protein signaling 8
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RGS8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Regulator of G protein signaling domain
  • Regulator of G protein signaling (RGS) domain superfamily
  • GTPase
  • GTPase activator
  • enzyme
  • protein binding

Pathways

Biological processes and signaling networks where the RGS8 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • survival
  • thyroid carcinoma
  • epithelial thyroid cancer
  • purkinje cell degeneration
regulated by
regulates
  • Ca2+
  • GIRK
  • N-type calcium channel
  • GTPase

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Nucleus
  • Plasma Membrane
  • cytoplasmic face of plasma membrane
  • perikaryon
  • dendrites

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human RGS8 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of signal transduction
  • G-protein coupled receptor signaling pathway
  • G-protein coupled acetylcholine receptor signaling pathway
  • regulation of dopamine receptor signaling pathway
  • positive regulation of GTPase activity

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • dendrite
  • neuronal cell body membrane
  • synapse
  • perikaryon
  • plasma membrane
  • internal side of plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • GTPase activity
  • GTPase activator activity

Gene-Specific Assays for Results You Can Trust

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