ZDHHC15 Gene Summary [Human]
The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | ZDHHC15 |
| Official Name | zinc finger DHHC-type palmitoyltransferase 15 [Source:HGNC Symbol;Acc:HGNC:20342] |
| Ensembl ID | ENSG00000102383 |
| Bio databases IDs | |
| Aliases | zinc finger DHHC-type palmitoyltransferase 15, Mental retardation, X-linked 91 |
| Synonyms | 6030457O13RIK, DHHC15, MRX91, zinc finger, DHHC domain containing 15, zinc finger DHHC-type palmitoyltransferase 15 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZDHHC15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyltransferase
- zinc ion binding
- protein-cysteine S-palmitoleyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- organismal death
- idiopathic scoliosis
- glioma
- glioma formation
- lung adenocarcinoma formation
- X-linked complex neurodevelopmental disorder
role in cell
- binding in
- proliferation
- migration
- development
- morphogenesis
- binding
- palmitoylation in
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- postsynaptic region
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZDHHC15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendritic spine morphogenesis
- peptidyl-L-cysteine S-palmitoylation
- protein localization in membrane
- protein palmitoylation
- synaptic vesicle maturation
- positive regulation of dendrite development
- protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- endoplasmic reticulum
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein-cysteine S-palmitoleyltransferase activity
- zinc ion binding
- protein-cysteine S-myristoyltransferase activity
- protein binding
- palmitoyltransferase activity