Zdhhc15 Gene Summary [Mouse]
Enables protein-cysteine S-palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Acts upstream of or within establishment of protein localization and synaptic vesicle maturation. Located in Golgi apparatus. Is expressed in embryo and eye. Orthologous to human ZDHHC15 (zinc finger DHHC-type palmitoyltransferase 15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zdhhc15 |
| Official Name | zinc finger, DHHC domain containing 15 [Source:MGI Symbol;Acc:MGI:1915336] |
| Ensembl ID | ENSMUSG00000033906 |
| Bio databases IDs | |
| Aliases | zinc finger, DHHC domain containing 15 |
| Synonyms | 6030457O13RIK, DHHC15, MRX91, zinc finger, DHHC domain containing 15, zinc finger DHHC-type palmitoyltransferase 15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zdhhc15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyltransferase
- zinc ion binding
- protein-cysteine S-palmitoleyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- organismal death
- idiopathic scoliosis
- glioma
- glioma formation
- lung adenocarcinoma formation
- X-linked complex neurodevelopmental disorder
role in cell
- binding in
- proliferation
- migration
- development
- morphogenesis
- binding
- palmitoylation in
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- postsynaptic region
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zdhhc15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendritic spine morphogenesis
- peptidyl-L-cysteine S-palmitoylation
- protein localization in membrane
- protein palmitoylation
- synaptic vesicle maturation
- positive regulation of dendrite development
- protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- endoplasmic reticulum
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein-cysteine S-palmitoleyltransferase activity
- zinc ion binding
- protein-cysteine S-myristoyltransferase activity
- protein binding
- palmitoyltransferase activity