ACOD1 Gene Summary [Human]
Enables aconitate decarboxylase activity. Involved in defense response; positive regulation of antimicrobial humoral response; and tolerance induction to lipopolysaccharide. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ACOD1 |
| Official Name | aconitate decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:33904] |
| Ensembl ID | ENSG00000102794 |
| Bio databases IDs | |
| Aliases | aconitate decarboxylase 1 |
| Synonyms | aconitate decarboxylase 1, CAD, IRG1, LOC100508024, RGD1563454 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ACOD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- aconitate decarboxylase
- protein homodimerization
- MmgE/PrpD C-terminal domain
- enzyme
- MmgE/PrpD N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- neoplasia
- coronary artery disease
- diabetes mellitus
- insulin resistance
- sepsis
- dextran sodium sulfate-induced colitis
- impaired glucose tolerance
- OVA-induced allergic lung inflammation
- K/BxN serum transfer arthritis
- infection by Salmonella enterica subsp. enterica serovar Typhimurium
role in cell
- expression in
- production in
- migration
- fragmentation
- phosphorylation in
- binding in
- upregulation in
- recruitment
- response by
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ACOD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of type I interferon production
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of toll-like receptor 4 signaling pathway
- negative regulation of inflammatory response
- defense response
- negative regulation of innate immune response
- positive regulation of antimicrobial humoral response
- embryo implantation
- inflammatory response
- cellular response to progesterone stimulus
- cellular response to lipopolysaccharide
- tolerance induction to lipopolysaccharide
- cellular response to interleukin-1
- defense response to virus
- negative regulation of toll-like receptor 2 signaling pathway
- cellular response to tumor necrosis factor
- cellular response to interferon-gamma
- cellular response to molecule of bacterial origin
- positive regulation of reactive oxygen species metabolic process
- cellular response to interferon-beta
Cellular Component
Where in the cell the gene product is active
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- aconitate decarboxylase activity