CENPT Gene Summary [Human]
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]
Details
| Type | Retained Intron |
| Official Symbol | CENPT |
| Official Name | centromere protein T [Source:HGNC Symbol;Acc:HGNC:25787] |
| Ensembl ID | ENSG00000102901 |
| Bio databases IDs | |
| Aliases | centromere protein T |
| Synonyms | C16orf56, centromere protein T, G630055P03Rik, LOC100041617, RGD1309383, SSMGA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CENPT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- Centromere kinetochore component CENP-T N-terminus
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear bodies
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CENPT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- chromosome organization
- kinetochore assembly
- chromosome segregation
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- condensed chromosome inner kinetochore
- nuclear body
- cytosol
- kinetochore
- chromosome, centromeric region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- protein heterodimerization activity