CENPW Gene Summary [Human]
Predicted to enable DNA binding activity and protein heterodimerization activity. Involved in chromosome segregation; kinetochore assembly; and mitotic cell cycle. Located in kinetochore and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CENPW |
| Official Name | centromere protein W [Source:HGNC Symbol;Acc:HGNC:21488] |
| Ensembl ID | ENSG00000203760 |
| Bio databases IDs | |
| Aliases | centromere protein W, cancer-upregulated gene 2 |
| Synonyms | 2610036L11Rik, C6orf173, centromere protein W, CUG2, LOC681870 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CENPW often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- CENP-W protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- septic shock
- androgenic alopecia
- bladder cancer
- Wilms tumor
- Wilms tumorigenesis
- drusen
regulates
role in cell
- proliferation
- apoptosis
- phosphorylation in
- G2/M phase
- assembly
- organization
- segregation
- misalignment in
- misalignment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CENPW gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- chromosome organization
- kinetochore assembly
- chromosome segregation
- mitotic cell cycle
- CenH3-containing nucleosome assembly at centromere
Cellular Component
Where in the cell the gene product is active
- nucleus
- condensed chromosome inner kinetochore
- nuclear matrix
- kinetochore
- chromosome, centromeric region
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- protein heterodimerization activity