CIAO3 Gene Summary [Human]
Predicted to enable 4 iron, 4 sulfur cluster binding activity. Involved in several processes, including iron-sulfur cluster assembly; oxygen homeostasis; and response to hypoxia. Part of CIA complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CIAO3 |
| Official Name | cytosolic iron-sulfur assembly component 3 [Source:HGNC Symbol;Acc:HGNC:14179] |
| Ensembl ID | ENSG00000103245 |
| Bio databases IDs | |
| Aliases | cytosolic iron-sulfur assembly component 3, iron-only hydrogenase-like protein 1 |
| Synonyms | 9030612I22RIK, cytosolic iron-sulfur assembly component 3, cytosolic iron-sulphur assembly component 3, HPRN, IOP1, LET1L, NAR1, NARFL, PRN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CIAO3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Iron hydrogenase small subunit
- protein binding
- Iron only hydrogenase large subunit, C-terminal domain
Pathways
Biological processes and signaling networks where the CIAO3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CIAO3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hypoxia
- regulation of gene expression
- oxygen homeostasis
- hemopoietic progenitor cell differentiation
- iron-sulfur cluster assembly
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- 4 iron, 4 sulfur cluster binding