ISCA1 Gene Summary [Human]
ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in electron-transfer reactions (Cozar-Castellano et al., 2004 [PubMed 15262227]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | ISCA1 |
| Official Name | iron-sulfur cluster assembly 1 [Source:HGNC Symbol;Acc:HGNC:28660] |
| Ensembl ID | ENSG00000135070 |
| Bio databases IDs | |
| Aliases | iron-sulfur cluster assembly 1 |
| Synonyms | 1810010A06RIK, HBLD2, hIscA, hIscA1, iron-sulfur cluster assembly 1, iron-sulphur cluster assembly 1, ISA1, MGC4276, MMDS5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ISCA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Iron-sulphur cluster biosynthesis
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- multiple mitochondrial dysfunctions syndrome
- multiple mitochondrial dysfunctions syndrome type 5
- metabolic syndrome X
role in cell
- survival
- enlargement
- enlargement in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ISCA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- 2 iron, 2 sulfur cluster binding