FBXO31 Gene Summary [Human]
This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Details
| Type | Protein Coding |
| Official Symbol | FBXO31 |
| Official Name | F-box protein 31 [Source:HGNC Symbol;Acc:HGNC:16510] |
| Ensembl ID | ENSG00000103264 |
| Bio databases IDs | |
| Aliases | F-box protein 31 |
| Synonyms | 1110003O08RIK, 2310046N15RIK, DKFZp434J1815, F-box protein 31, FBX14, Fbx31, FBXO14, MGC15419, MRT45, PP2386, RGD1561069 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXO31 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- F-box domain superfamily
- F-box-like
- protein binding activity, bridging
- enzyme
- protein binding
- Cyclin D1 binding domain
- cyclin binding
- RXXR motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diffuse large B-cell lymphoma
- organismal death
- pancreatic epithelial cancer
- pancreatic adenocarcinoma
- spastic cerebral palsy
- autosomal recessive mental retardation type 45
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
role in cell
- activation in
- invasion by
- apoptosis
- signaling in
- cell viability
- migration
- growth
- morphogenesis
- invasiveness
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- centrosome
- Mitochondria
- cytosol
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXO31 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G1/S transition DNA damage checkpoint
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- response to DNA damage stimulus
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytosol
- SCF ubiquitin ligase complex
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- protein binding
- cyclin binding