CDT1 Gene Summary [Human]
The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]
Details
| Type | Protein Coding |
| Official Symbol | CDT1 |
| Official Name | chromatin licensing and DNA replication factor 1 [Source:HGNC Symbol;Acc:HGNC:24576] |
| Ensembl ID | ENSG00000167513 |
| Bio databases IDs | |
| Aliases | chromatin licensing and DNA replication factor 1 |
| Synonyms | 2610318F11Rik, chromatin licensing and DNA replication factor 1, DUP, RIS2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PCNA binding domain
- chromatin binding
- Cdt1 middle winged helix domain
- protein binding
- PIP degron
- cyclin-binding domain
- Cdt1_c
- DNA binding
- cyclin-CDK binding domain
Pathways
Biological processes and signaling networks where the CDT1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Meier-Gorlin syndrome type 4
- lung adenocarcinoma
- lung adenocarcinoma formation
- Meier-Gorlin syndrome
- organismal death
- MYC mutation positive B-cell lymphoma
- lymphomagenesis
- B cell cancer
- mammary neoplasm
role in cell
- replication in
- expression in
- phosphorylation in
- growth
- cell death
- cell cycle progression
- degradation in
- re-replication in
- damage in
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- chromatin fraction
- insoluble fractions
- nucleoplasm
- nucleoli
- nuclear bodies
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to sorbitol
- positive regulation of chromatin binding
- regulation of DNA-dependent DNA replication initiation
- regulation of DNA replication involved in S phase
- negative regulation of cell cycle
- positive regulation of DNA replication
- mitotic cell cycle
- cell division
- DNA replication preinitiation complex assembly
- DNA replication checkpoint
- positive regulation of DNA-dependent DNA replication
- negative regulation of DNA-dependent DNA replication
- attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- kinetochore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- DNA polymerase binding
- protein binding
- chromatin binding