TOX3 Gene Summary [Human]
The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
Details
| Type | Protein Coding |
| Official Symbol | TOX3 |
| Official Name | TOX high mobility group box family member 3 [Source:HGNC Symbol;Acc:HGNC:11972] |
| Ensembl ID | ENSG00000103460 |
| Bio databases IDs | |
| Aliases | TOX high mobility group box family member 3 |
| Synonyms | 500-9, C230068E13, CAGF9, TNRC9, TOX high mobility group box family member 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TOX3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- high mobility group (HMG)-box domain superfamily
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- phosphoprotein binding
- protein homodimerization
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- cancer
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- breast carcinoma
- insomnia
- Parkinson disease
- herpes zoster
- restless legs syndrome
role in cell
- expression in
- apoptosis
- cell death
- binding in
- trimethylation in
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TOX3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- regulation of apoptotic process
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- protein binding
- protein homodimerization activity
- transcription coactivator activity
- phosphoprotein binding
- chromatin binding