SSR1 Gene Summary [Human]
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Details
| Type | Protein Coding |
| Official Symbol | SSR1 |
| Official Name | signal sequence receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:11323] |
| Ensembl ID | ENSG00000124783 |
| Bio databases IDs | |
| Aliases | signal sequence receptor subunit 1, translocon-associated protein alpha |
| Synonyms | 2510001K09Rik, 6330400D04, Ac2-238, AI452176, signal sequence receptor, alpha, signal sequence receptor subunit 1, signal sequence receptor, α, Signal sequence receptor α subunit, SSR, SSR alpha, SSR α, Translocon associated protein α, TRAPA, Trap alpha, Trap α |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SSR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Translocon-associated protein (TRAP), alpha subunit
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- insomnia
- non-insulin-dependent diabetes mellitus
- vascular dementia
- major depression
- refractive error
- myopia
- productive infection by HIV-1
regulates
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SSR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cotranslational protein targeting to membrane
- positive regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding