STX4 Gene Summary [Human]
Enables sphingomyelin phosphodiesterase activator activity. Involved in several processes, including cornified envelope assembly; positive regulation of immune effector process; and positive regulation of protein localization. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and lamellipodium. Part of SNARE complex. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | STX4 |
| Official Name | syntaxin 4 [Source:HGNC Symbol;Acc:HGNC:11439] |
| Ensembl ID | ENSG00000103496 |
| Bio databases IDs | |
| Aliases | syntaxin 4 |
| Synonyms | DFNB123, LOC101928762, p35-2, STX4A, Syn-4, Syntaxin 4, syntaxin 4A (placental) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STX4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- SNAP receptor
- regulatory domain
- sphingomyelin phosphodiesterase activator
- enzyme binding
- coiled-coil domain
- protein binding
- SynN
- cytoplasmic domain
- SNARE domain
- Helical region found in SNAREs
- transmembrane domain
- Syntaxin
- SNARE motif
- transmembrane receptor
- transporter
Pathways
Biological processes and signaling networks where the STX4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sensorineural hearing loss
- insomnia
- autosomal recessive deafness type 123
- insulin resistance
role in cell
- invasion
- migration
- proliferation
- binding in
- apoptosis
- activation in
- induction in
- activation
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- invadopodia
- cell surface
- Extracellular Space
- cell periphery
- somatodendritic region
- perinuclear region
- postsynaptic region
- membrane surface
- cellular membrane
- vacuole
- endosomes
- vesicles
- cell-cell contacts
- granules
- cytosol
- stereocilia
- apical membrane
- postsynaptic membrane
- basolateral membrane
- basal membrane
- trans Golgi network
- mitochondrial outer membrane
- alpha granules
- dendritic spines
- neurites
- myelin sheath inner loop
- myelin sheath
- synapse
- sarcolemma
- recycling endosomes
- transverse tubules
- specific granules
- membrane rafts
- phagosomes
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STX4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization at cell surface
- positive regulation of protein localization at cell surface
- SNARE complex assembly
- positive regulation of cell proliferation
- positive regulation of eosinophil degranulation
- positive regulation of cell adhesion
- intracellular protein transport
- exocytosis
- neurotransmitter transport
- organelle fusion
- vesicle fusion
- positive regulation of catalytic activity
- vesicle docking
- positive regulation of immunoglobulin production
- cellular response to oxidative stress
- long-term synaptic potentiation
- regulation of exocytosis
- cellular response to interferon-gamma
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- positive regulation of chemotaxis
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- lateral loop
- synapse
- vacuole
- plasma membrane
- storage vacuole
- cell surface
- extracellular space
- trans-Golgi network
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- endosome
- myelin sheath adaxonal region
- specific granule
- dendritic spine
- membrane
- cytosol
- endomembrane system
- SNARE complex
- phagocytic vesicle membrane
- basolateral plasma membrane
- neuron projection membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- SNAP receptor activity
- sphingomyelin phosphodiesterase activator activity
- SNARE binding