NUMB Gene Summary [Human]
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | NUMB |
| Official Name | NUMB endocytic adaptor protein [Source:HGNC Symbol;Acc:HGNC:8060] |
| Ensembl ID | ENSG00000133961 |
| Bio databases IDs | |
| Aliases | NUMB endocytic adaptor protein |
| Synonyms | c14 5527, C14ORF41, Nb, NUMB endocytic adaptor protein, NUMB, endocytic adaptor protein, S171 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NUMB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-catenin binding
- NUMB domain
- beta-catenin binding
- NPF motif
- PTBi domain
- cadherin binding
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- PTBo domain
- proline rich domain
- DPF domain
Pathways
Biological processes and signaling networks where the NUMB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hypertension
- epithelial cancer
- tumorigenesis
- kidney carcinoma
- renal cancer
- colorectal carcinomagenesis
- colorectal cancer
- growth failure
- metastasis
role in cell
- apoptosis
- phosphorylation in
- expression in
- activation in
- accumulation in
- cell death
- growth
- differentiation
- degradation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- glutaminergic synapse
- Cytoplasm
- cell surface
- cell periphery
- apical compartment
- cellular membrane
- Nucleus
- endosomes
- vesicles
- Golgi Apparatus
- granules
- cytosol
- apical cell surfaces
- apical membrane
- basolateral membrane
- basal membrane
- trans Golgi network
- dendritic spines
- synaptic vesicles
- growth cone
- early endosomes
- cytoplasmic vesicles
- cleavage furrow
- clathrin-coated pits
- perikaryon
- dendrites
- postsynaptic density
- clathrin-coated vesicles
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NUMB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuroblast division in subventricular zone
- lateral ventricle development
- adherens junction organization
- axonogenesis
- positive regulation of neurogenesis
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- early endosome
- focal adhesion
- apical part of cell
- cytoplasm
- coated pit
- cytoplasmic vesicle
- endosome membrane
- clathrin-coated vesicle
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- alpha-catenin binding
- protein binding
- cadherin binding
- beta-catenin binding