CEP152 Gene Summary [Human]
This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | CEP152 |
| Official Name | centrosomal protein 152 [Source:HGNC Symbol;Acc:HGNC:29298] |
| Ensembl ID | ENSG00000103995 |
| Bio databases IDs | |
| Aliases | centrosomal protein 152, asterless |
| Synonyms | centrosomal protein 152, LOC102555758, MCPH4, MCPH9, mKIAA0912, RGD1305348, SCKL5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CEP152 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha helical coiled-coil rod protein (HCR)
- RecF/RecN/SMC N terminal domain
- chromosome segregation protein SMC, common bacterial type
- exonuclease SbcC
- protein kinase binding
- Synaptonemal complex protein 1 (SCP-1)
- helix-rich Mycoplasma protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pericentriolar matrix
- organelle
- basal bodies
- centrosome
- centriole
- cytosol
- nucleoplasm
- nuclear bodies
- pro-centriole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CEP152 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centriole replication
- centrosome duplication
- cell projection organization
Cellular Component
Where in the cell the gene product is active
- pericentriolar material
- centrosome
- centriole
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding