ULK4 Gene Summary [Human]
This gene encodes a member of the unc-51-like serine/threonine kinase (STK) family. Members of this protein family play a role in neuronal growth and endocytosis. The encoded protein is likely involved in neurite branching, neurite elongation and neuronal migration. Genome-wide association studies (GWAS) indicate an association of variations in this gene with blood pressure and hypertension. Sequence variations in this gene may also be be associated with psychiatric disorders, including schizophrenia and bipolar disorder. Pseudogenes associated with this gene have been identified and are located on chromosome 15. [provided by RefSeq, Jul 2016]
Details
| Type | Processed Transcript |
| Official Symbol | ULK4 |
| Official Name | unc-51 like kinase 4 [Source:HGNC Symbol;Acc:HGNC:15784] |
| Ensembl ID | ENSG00000168038 |
| Bio databases IDs | |
| Aliases | unc-51 like kinase 4 |
| Synonyms | 4932415A06RIK, A730098P15, DKFZP434E1822, FAM7C1, REC01035, RGD1565726, unc-51-like kinase 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ULK4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- schizophrenia
- alcoholic liver disease
- myopia
- plasma cell myeloma
- paraproteinemia
- major depression
- ischemic stroke
- alcoholism
- hypertension
role in cell
- quantity
- differentiation
- movement
- assembly
- development
- disorganization
- organization
- migration by
- number
- disorganization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ULK4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- regulation of protein kinase C signaling cascade
- microtubule cytoskeleton organization
- regulation of neuron projection development
- regulation of p38MAPK cascade
- regulation of neuron migration
- regulation of JNK cascade
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein serine/threonine kinase activity