CDK13 Gene Summary [Human]
The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009]
Details
| Type | Protein Coding |
| Official Symbol | CDK13 |
| Official Name | cyclin dependent kinase 13 [Source:HGNC Symbol;Acc:HGNC:1733] |
| Ensembl ID | ENSG00000065883 |
| Bio databases IDs | |
| Aliases | cyclin dependent kinase 13, cholinesterase-related cell division controller |
| Synonyms | 2310015O17Rik, CDC2L, CDC2L5, CDC2-RELATED protein KINASE 5, CHDFIDD, CHED, cyclin-dependent kinase 13, hCDK13 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDK13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- [RNA-polymerase]-subunit kinase
- protein kinase
- protein kinase binding
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- cyclin binding
Pathways
Biological processes and signaling networks where the CDK13 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital heart defects, dysmorphic facial features and intellectual developmental disorder
- pervasive developmental disorder
- gastroesophageal reflux
- syndromic congenital heart disease
- hereditary disorder
- marfanoid habitus with mental retardation
- immune thrombocytopenia
- tumorigenesis
- growth failure
- clear-cell ovarian carcinoma
regulated by
- TCR (complex)
- gentamicin
- SCp2 cells
- cyclosporin A
- Exendin4
- NLRP3
- mir-133 (includes others)
- SR4835
- THZ531
- SM1-71
role in cell
- production in
- phosphorylation in
- proliferation
- expression in
- cell death
- cell viability
- synthesis in
- differentiation
- production
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ficolin-1-rich granule lumen
- Extracellular Space
- Golgi Apparatus
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDK13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- alternative nuclear mRNA splicing, via spliceosome
- hemopoiesis
- negative regulation of stem cell differentiation
- regulation of cell cycle
- protein phosphorylation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- nuclear cyclin-dependent protein kinase holoenzyme complex
- nuclear speck
- cytosol
- Golgi apparatus
- positive transcription elongation factor complex b
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- protein binding
- RNA binding
- RNA polymerase II carboxy-terminal domain kinase activity
- protein kinase activity
- cyclin binding
- cyclin-dependent protein kinase activity