SIGLEC6 Gene Summary [Human]
This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | SIGLEC6 |
| Official Name | sialic acid binding Ig like lectin 6 [Source:HGNC Symbol;Acc:HGNC:10875] |
| Ensembl ID | ENSG00000105492 |
| Bio databases IDs | |
| Aliases | sialic acid binding Ig like lectin 6 |
| Synonyms | CD327, CD33L, CD33L1, CD33L2, CDW327, OBBP1, sialic acid binding Ig like lectin 6 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIGLEC6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- cellular membrane
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIGLEC6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-cell signaling
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- sialic acid binding
- carbohydrate binding