FHL2 Gene Summary [Human]
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | FHL2 |
| Official Name | four and a half LIM domains 2 [Source:HGNC Symbol;Acc:HGNC:3703] |
| Ensembl ID | ENSG00000115641 |
| Bio databases IDs | |
| Aliases | four and a half LIM domains 2 |
| Synonyms | AAG11, DRAL, four and a half LIM domains 2, Skeletal muscle lim protein 3, SLIM-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FHL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- half LIM domain
- transcription co-repressor
- transcription factor binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- fibrosis
- weight gain
- organismal death
- prostate cancer
- osteoporosis
- cardiac hypertrophy
- primary myelofibrosis
- breast carcinoma
- lung adenocarcinoma
role in cell
- activation in
- binding in
- expression in
- phosphorylation in
- migration
- cellular infiltration by
- invasion
- proliferation
- number
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- membrane fraction
- cytoskeleton
- Cytoplasm
- cell periphery
- cellular membrane
- focal adhesions
- Plasma Membrane
- actin filaments
- sarcomere
- cytosol
- nuclear foci
- nucleoplasm
- m-bands
- Z line
- fibrils
- actin stress fibers
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FHL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of apoptotic process
- negative regulation of calcineurin-NFAT signaling cascade
- osteoblast differentiation
- atrial cardiac muscle cell development
- ventricular cardiac muscle cell development
- response to hormone stimulus
- heart trabecula formation
Cellular Component
Where in the cell the gene product is active
- nucleus
- Z disc
- focal adhesion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transcription cofactor activity
- metal ion binding
- transcription corepressor activity
- transcription factor binding
- bHLH transcription factor binding