GRIK5 Gene Summary [Human]
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Details
| Type | Retained Intron |
| Official Symbol | GRIK5 |
| Official Name | glutamate ionotropic receptor kainate type subunit 5 [Source:HGNC Symbol;Acc:HGNC:4583] |
| Ensembl ID | ENSG00000105737 |
| Bio databases IDs | |
| Aliases | glutamate ionotropic receptor kainate type subunit 5 |
| Synonyms | EAA2, GluK5, GluRgamma2, glutamate ionotropic receptor kainate type subunit 5, glutamate receptor, ionotropic, kainate 5 (gamma 2), glutamate receptor, ionotropic, kainate 5 (γ 2), GRIK2, iGlu5, KA2, KA2r |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRIK5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Receptor family ligand binding region
- channel/pore class transporter
- Ligated ion channel L-glutamate- and glycine-binding site
- ionotropic glutamate receptor
- extracellular ligand-gated ion channel
- protein binding
- proline rich domain
- identical protein binding
- ion channel
- SH3-domain binding
- glutamate receptor
- PDZ-domain binding
- kainate selective glutamate receptor
- neurotransmitter receptor
- cytoplasmic domain
- Type 1 periplasmic binding fold superfamily
- Type 2 periplasmic binding fold superfamily
- ligand-gated ion channel
Pathways
Biological processes and signaling networks where the GRIK5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- bipolar disorder
- acute myeloid leukemia
- hypothyroidism
regulates
- GRIK5
- L-glutamic acid
- receptor
role in cell
- apoptosis
- transmembrane potential
- transmission
- depolarization
- retention in
- action potential in
- paired-pulse facilitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cellular membrane
- Endoplasmic Reticulum
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- nucleoplasm
- nerve ending
- synaptosomes
- synapse
- membrane processes
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRIK5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- ion transmembrane transport
- regulation of synaptic transmission
- regulation of synaptic vesicle fusion to presynaptic membrane
- ionotropic glutamate receptor signaling pathway
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- kainate selective glutamate receptor complex
- endoplasmic reticulum
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- kainate selective glutamate receptor activity
- ionotropic glutamate receptor activity