NETO1 Gene Summary [Human]
This gene encodes a transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. This protein is thought to play a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | NETO1 |
| Official Name | neuropilin and tolloid like 1 [Source:HGNC Symbol;Acc:HGNC:13823] |
| Ensembl ID | ENSG00000166342 |
| Bio databases IDs | |
| Aliases | neuropilin and tolloid like 1 |
| Synonyms | AI851453, BCTL1, BTCL1, C130005O10Rik, neuropilin and tolloid like 1, neuropilin (NRP) and tolloid (TLL)-like 1, RGD1566269 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NETO1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CUB
- LDLa
- protein binding
- ionotropic glutamate receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- global developmental delay with intellectual disability
- pervasive developmental disorder
- tinnitus
- exostoses
- cleft palate
- cleft lip
- idiopathic scoliosis
- Cornelia de Lange syndrome
role in cell
- desensitization in
- neurotransmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- cellular membrane
- synaptic membrane
- synaptosomes
- synapse
- postsynaptic density
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NETO1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of long-term neuronal synaptic plasticity
- visual learning
- positive regulation of excitatory postsynaptic membrane potential
- memory
- regulation of kainate selective glutamate receptor activity
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- excitatory synapse
- extracellular region
Molecular Function
What the gene product does at the molecular level
- ionotropic glutamate receptor binding