Grik5 Gene Summary [Mouse]
Enables kainate selective glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within excitatory postsynaptic potential; glutamatergic synaptic transmission; and regulation of synaptic vesicle fusion to presynaptic active zone membrane. Located in endoplasmic reticulum and postsynaptic membrane. Part of kainate selective glutamate receptor complex. Is active in hippocampal mossy fiber to CA3 synapse; postsynaptic density membrane; and presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and visual system. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human GRIK5 (glutamate ionotropic receptor kainate type subunit 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Grik5 |
| Official Name | glutamate receptor, ionotropic, kainate 5 (gamma 2) [Source:MGI Symbol;Acc:MGI:95818] |
| Ensembl ID | ENSMUSG00000003378 |
| Bio databases IDs | |
| Aliases | glutamate receptor, ionotropic, kainate 5 (gamma 2) |
| Synonyms | EAA2, GluK5, GluRgamma2, glutamate ionotropic receptor kainate type subunit 5, glutamate receptor, ionotropic, kainate 5 (gamma 2), glutamate receptor, ionotropic, kainate 5 (γ 2), GRIK2, iGlu5, KA2, KA2r |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grik5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Receptor family ligand binding region
- channel/pore class transporter
- Ligated ion channel L-glutamate- and glycine-binding site
- ionotropic glutamate receptor
- extracellular ligand-gated ion channel
- protein binding
- proline rich domain
- identical protein binding
- ion channel
- SH3-domain binding
- glutamate receptor
- PDZ-domain binding
- kainate selective glutamate receptor
- neurotransmitter receptor
- cytoplasmic domain
- Type 1 periplasmic binding fold superfamily
- Type 2 periplasmic binding fold superfamily
- ligand-gated ion channel
Pathways
Biological processes and signaling networks where the Grik5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- bipolar disorder
- acute myeloid leukemia
- hypothyroidism
regulates
- GRIK5
- L-glutamic acid
- receptor
role in cell
- apoptosis
- transmembrane potential
- transmission
- depolarization
- retention in
- action potential in
- paired-pulse facilitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cellular membrane
- Endoplasmic Reticulum
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- nucleoplasm
- nerve ending
- synaptosomes
- synapse
- membrane processes
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grik5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- ion transmembrane transport
- regulation of synaptic transmission
- regulation of synaptic vesicle fusion to presynaptic membrane
- ionotropic glutamate receptor signaling pathway
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- kainate selective glutamate receptor complex
- endoplasmic reticulum
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- kainate selective glutamate receptor activity
- ionotropic glutamate receptor activity