AP1S1
AP1S1 Gene Summary
The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | AP1S1 |
| Official Name | adaptor related protein complex 1 subunit sigma 1 [Source:HGNC Symbol;Acc:HGNC:559] |
| Ensembl ID | ENSG00000106367 |
| Bio databases IDs | |
| Aliases | adaptor related protein complex 1 subunit sigma 1, clathrin-associated/assembly/adaptor protein, small 1 (19kD), clathrin coat assembly protein AP19, sigma1A subunit of AP-1 clathrin adaptor complex, AP-1 complex subunit sigma-1A, sigma1A-adaptin, golgi adaptor HA1/AP1 adaptin sigma-1A subunit, clathrin assembly protein complex 1 sigma-1A small chain, HA1 19 kDa subunit |
| Synonyms | adaptor protein complex AP-1, sigma 1,adaptor protein complex AP-1, σ 1,adaptor related protein complex 1 subunit sigma 1,adaptor related protein complex 1 subunit σ 1,AP19,Ap1s1 predicted,CLAPS1,EKV3,MEDNIK,SIGMA1A |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Clathrin adaptor complex small chain
- APS2
- protein binding
- Longin-like domains
- transporter
Pathways
Biological processes and signaling networks where the AP1S1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TUBA1A
- BRD4
- RPA1
- TRIM67
- TIPARP
- SEC61A1
- AP2 alpha
- AP1 gamma
- AP1M1
- EGFR
disease
- hereditary disorder
- erythrokeratodermia variabilis type 3
- metabolic syndrome X
- Huntington disease
- febrile seizure
- flu
regulated by
- TFEB
- medroxyprogesterone acetate
- ESR1
- IFNG
- beta-estradiol
- TSC2
- CTBP
- 8-bromo-cAMP
- MITF
- N-[5-(4-bromobenzylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]naphthalene-1-sulfonamide
regulates
- M06
- MHC I (complex)
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- presynaptic regions
- Plasma Membrane
- Golgi Apparatus
- cytosol
- Golgi membrane
- trans Golgi network
- lysosome membrane
- axon terminals
- clathrin-coated vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the AP1S1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- platelet dense granule organization
- vesicle-mediated transport
- intracellular protein transport
- response to virus
- receptor-mediated endocytosis
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- early endosome
- coated pit
- intracellular membrane-bounded organelle
- membrane
- AP-1 adaptor complex
- cytosol
- Golgi apparatus
- Golgi membrane
- lysosomal membrane
- trans-Golgi network membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- clathrin adaptor activity