Ap1s1 Gene Summary [Mouse]
Predicted to enable clathrin adaptor activity. Acts upstream of or within retrograde transport, endosome to Golgi. Located in terminal bouton. Is active in presynapse. Human ortholog(s) of this gene implicated in MEDNIK syndrome. Orthologous to human AP1S1 (adaptor related protein complex 1 subunit sigma 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ap1s1 |
| Official Name | adaptor protein complex AP-1, sigma 1 [Source:MGI Symbol;Acc:MGI:1098244] |
| Ensembl ID | ENSMUSG00000004849 |
| Bio databases IDs | |
| Aliases | adaptor protein complex AP-1, sigma 1 |
| Synonyms | adaptor protein complex AP-1, sigma 1, adaptor protein complex AP-1, σ 1, adaptor related protein complex 1 subunit sigma 1, adaptor related protein complex 1 subunit σ 1, AP19, Ap1s1 predicted, CLAPS1, EKV3, MEDNIK, SIGMA1A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ap1s1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Clathrin adaptor complex small chain
- APS2
- protein binding
- Longin-like domains
- transporter
Pathways
Biological processes and signaling networks where the Ap1s1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- erythrokeratodermia variabilis type 3
- metabolic syndrome X
- Huntington disease
- febrile seizure
- flu
regulates
- M06
- MHC I (complex)
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- presynaptic regions
- Plasma Membrane
- Golgi Apparatus
- cytosol
- Golgi membrane
- trans Golgi network
- lysosome membrane
- axon terminals
- clathrin-coated vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ap1s1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- platelet dense granule organization
- vesicle-mediated transport
- intracellular protein transport
- response to virus
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- early endosome
- coated pit
- intracellular membrane-bounded organelle
- membrane
- AP-1 adaptor complex
- cytosol
- Golgi apparatus
- Golgi membrane
- lysosomal membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- clathrin adaptor activity