CLIP2 Gene Summary [Human]
The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CLIP2 |
| Official Name | CAP-Gly domain containing linker protein 2 [Source:HGNC Symbol;Acc:HGNC:2586] |
| Ensembl ID | ENSG00000106665 |
| Bio databases IDs | |
| Aliases | CAP-Gly domain containing linker protein 2 |
| Synonyms | B230327O20, CAP-GLY domain containing linker protein 2, CLIP, Clip1, CLIP-115, CYLN2, Cytoplasmic Linker 2, mKIAA0291, WBSCR3, WBSCR4, WSCR3, WSCR4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLIP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HAP1 N-terminal conserved region
- Mitotic checkpoint protein
- microtubule binding domain
- transcription regulator
- Synaptonemal complex protein 1 (SCP-1)
- CAP-Gly domain
- helix-rich Mycoplasma protein
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Putative golgin subfamily A member 2-like protein 5
- microtubule binding
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- microtubule plus-end binding
- Intermediate filament protein
- CAP_GLY
- HOOK protein coiled-coil region
- Domain of unknown function (DUF4200)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- systemic lupus erythematosus
- myasthenia gravis
- SAPHO syndrome
regulated by
- thioacetamide
- hydroxypropyl-beta-cyclodextrin
- halofuginone
- KF1B
- N-[N-(3,5-difluorophenacetyl-L-Ala)]-S-phenylglycine t-butyl ester
- MIR3648
- THP-1 cells
- macrophages
- glucocorticoid
- LDL
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cytoskeleton
- microtubules
- microtubule tips
- dendritic lamellar bodies
- alveolar epithelial lamellar bodies
- cytoplasmic microtubule
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLIP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic microtubule organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule plus end
- cell cortex
- microtubule associated complex
Molecular Function
What the gene product does at the molecular level
- microtubule plus-end binding
- microtubule binding