CLIP1 Gene Summary [Human]
The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | CLIP1 |
| Official Name | CAP-Gly domain containing linker protein 1 [Source:HGNC Symbol;Acc:HGNC:10461] |
| Ensembl ID | ENSG00000130779 |
| Bio databases IDs | |
| Aliases | CAP-Gly domain containing linker protein 1, restin |
| Synonyms | 1110007I12Rik, 4631429H07Rik, CAP-GLY domain containing linker protein 1, CLIP, CLIP-170, Clip50, CYLN1, mKIAA4046, restin, RSN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CLIP1 zinc knuckle
- Synaptonemal complex protein 1 (SCP-1)
- helix-rich Mycoplasma protein
- coiled-coil domain
- tandem repeat
- head domain
- identical protein binding
- YSPTSPS repeat
- metal binding domain
- N2 domain
- chromosome segregation protein SMC, common bacterial type
- serine-rich region
- zinc ion binding
- tubulin binding
- Mitotic checkpoint protein
- Crescentin protein
- microtubule binding domain
- chromosome segregation protein SMC, primarily archaeal type
- LXG domain of WXG superfamily
- exonuclease SbcC
- Weak chloroplast movement under blue light
- zinc finger-like domain
- rad50
- CAP-Gly domain
- Myosin tail
- protein binding
- Protein of unknown function (DUF3584)
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Alpha helical coiled-coil rod protein (HCR)
- microtubule binding
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- Coiled-coil domain-containing protein 158
- microtubule plus-end binding
- Intermediate filament protein
- CAP_GLY
- Septation ring formation regulator, EzrA
- LIS1 binding domain
Pathways
Biological processes and signaling networks where the CLIP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- infection by human herpesvirus 1
role in cell
- activation in
- expression in
- binding in
- formation
- degradation in
- cell cycle progression
- growth
- development
- binding
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cytoskeleton
- cell periphery
- manchette
- cell cortex
- Plasma Membrane
- spindle pole bodies
- centrosome
- microtubules
- intermediate filaments
- growing ends of microtubules
- microtubule bundles
- microtubule tips
- cytosol
- centromeric region
- membrane ruffles
- chromosome
- perinuclear space
- nuclear envelope
- cytoplasmic microtubule
- plus end of microtubule
- kinetochores
- perikaryon
- axons
- dendrites
- macropinosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLIP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule bundle formation
- cytoplasmic microtubule organization
- positive regulation of microtubule polymerization
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- microtubule plus end
- macropinosome
- intermediate filament
- kinetochore
- microtubule
- nucleus
- centrosome
- cytoplasmic vesicle membrane
- cell cortex
- ruffle
- cytosol
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- zinc ion binding
- protein binding
- microtubule plus-end binding
- microtubule binding