Clip2 Gene Summary [Mouse]
Enables microtubule plus-end binding activity. Predicted to be involved in cytoplasmic microtubule organization. Located in microtubule plus-end. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; limb; and trigeminal nerve. Used to study Williams-Beuren syndrome. Orthologous to human CLIP2 (CAP-Gly domain containing linker protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clip2 |
| Official Name | CAP-GLY domain containing linker protein 2 [Source:MGI Symbol;Acc:MGI:1313136] |
| Ensembl ID | ENSMUSG00000063146 |
| Bio databases IDs | |
| Aliases | CAP-GLY domain containing linker protein 2 |
| Synonyms | B230327O20, CAP-GLY domain containing linker protein 2, CLIP, Clip1, CLIP-115, CYLN2, Cytoplasmic Linker 2, mKIAA0291, WBSCR3, WBSCR4, WSCR3, WSCR4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clip2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HAP1 N-terminal conserved region
- Mitotic checkpoint protein
- microtubule binding domain
- transcription regulator
- Synaptonemal complex protein 1 (SCP-1)
- CAP-Gly domain
- helix-rich Mycoplasma protein
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Putative golgin subfamily A member 2-like protein 5
- microtubule binding
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- microtubule plus-end binding
- Intermediate filament protein
- CAP_GLY
- HOOK protein coiled-coil region
- Domain of unknown function (DUF4200)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- systemic lupus erythematosus
- myasthenia gravis
- SAPHO syndrome
regulated by
- thioacetamide
- hydroxypropyl-beta-cyclodextrin
- halofuginone
- KF1B
- N-[N-(3,5-difluorophenacetyl-L-Ala)]-S-phenylglycine t-butyl ester
- MIR3648
- THP-1 cells
- macrophages
- glucocorticoid
- LDL
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cytoskeleton
- microtubules
- microtubule tips
- dendritic lamellar bodies
- alveolar epithelial lamellar bodies
- cytoplasmic microtubule
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clip2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic microtubule organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule plus end
- cell cortex
- microtubule associated complex
Molecular Function
What the gene product does at the molecular level
- microtubule plus-end binding
- microtubule binding