TRIM9 Gene Summary [Human]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRIM9 |
| Official Name | tripartite motif containing 9 [Source:HGNC Symbol;Acc:HGNC:16288] |
| Ensembl ID | ENSG00000100505 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 9, SNAP-25-interacting RING finger protein |
| Synonyms | C030048G07RIK, RNF91, SPRING, tripartite motif-containing 9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- B-Box C-terminal domain
- SPRY domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- protein domain specific binding
- protein binding
- Fibronectin type 3 domain
- SNAP-25 binding domain
- B-box-type zinc finger superfamily
- FN3
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- protein homodimerization
- B-box zinc finger
- SPRY-associated domain
Pathways
Biological processes and signaling networks where the TRIM9 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic colorectal cancer
- breast cancer
- esophageal cancer
- coronary artery disease
- psychosis
- organismal death
- epileptic seizure
role in cell
- activation in
- expression in
- differentiation
- proliferation
- production in
- phosphorylation in
- migration
- 5-fluorouracil resistance
- gemcitabine sensitivity
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosolic synaptosomal fraction
- membrane fraction
- microtubules
- synaptic vesicles
- synaptosomes
- dendrites
- synaptic vesicle fractions
- cytoskeletal fraction
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoskeleton
- cytoplasm
- synaptic vesicle
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein domain specific binding
- protein homodimerization activity
- protein binding