RIC1 Gene Summary [Human]
Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including positive regulation of GTPase activity; regulation of extracellular matrix constituent secretion; and retrograde transport, endosome to Golgi. Located in cytosol and membrane. Part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RIC1 |
| Official Name | RIC1 homolog, RAB6A GEF complex partner 1 [Source:HGNC Symbol;Acc:HGNC:17686] |
| Ensembl ID | ENSG00000107036 |
| Bio databases IDs | |
| Aliases | RIC1 homolog, RAB6A GEF complex partner 1 |
| Synonyms | bA207C16.1, C030046E11Rik, C130057E09Rik, CATIFA, CIP150, KIAA1432, RAB6A GEF complex partner 1, RGD1310016, RIC1 homolog, RAB6A GEF complex partner 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RIC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RIC1
- guanyl-nucleotide exchange factor
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RIC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein catabolic process
- regulation of extracellular matrix constituent secretion
- retrograde transport, endosome to Golgi
- intracellular protein transport
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- Ric1p-Rgp1p complex
- membrane
- cytosol
- Golgi membrane
- macromolecular complex
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding