MAP1LC3B Gene Summary [Human]
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MAP1LC3B |
| Official Name | microtubule associated protein 1 light chain 3 beta [Source:HGNC Symbol;Acc:HGNC:13352] |
| Ensembl ID | ENSG00000140941 |
| Bio databases IDs | |
| Aliases | microtubule associated protein 1 light chain 3 beta |
| Synonyms | 1010001C15Rik, Atg8, ATG8F, Jhl1, LC3, LC3B, lc3-II, MAP1A/1BLC3, MAP1A/MAP1B, MAP1LC3, MAP1LC3B-a, microtubule-associated protein 1 light chain 3 beta, microtubule-associated protein 1 light chain 3 β, Mpl3, zbs559 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP1LC3B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- ubiquitin protein ligase binding
- sphingolipid binding
- binding protein
- tubulin binding
- Ubl1_cv_Nsp3_N-like
- phosphatidylethanolamine binding
- protein domain specific binding
- protein binding
Pathways
Biological processes and signaling networks where the MAP1LC3B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- experimentally induced pancreatitis
- diabetic nephropathy
- organismal death
- diabetic retinopathy
- bleomycin-induced lung injury
- bleomycin-induced pulmonary fibrosis
- refractive error
- ductal breast carcinoma
- ductal breast cancer
role in cell
- expression in
- apoptosis
- cell viability
- cell death
- formation
- proliferation
- quantity
- senescence
- assembly
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- autophagosomal membrane
- intracellular membrane-bounded organelle
- presynaptic regions
- cellular membrane
- Nucleus
- lysosome
- Mitochondria
- axonemes
- cytosol
- photoreceptor inner segments
- autophagic vacuoles
- cytoplasmic vesicles
- autolysosomes
- chromatin
- perikaryon
- axons
- dendrites
- phagosomes
- autophagosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP1LC3B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- autophagy
- cellular response to starvation
- macromitophagy
- mitochondrion degradation
- macroautophagy
- cellular response to nitrogen starvation
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- intracellular membrane-bounded organelle
- mitochondrion
- endomembrane system
- cytoplasmic vesicle
- cytosol
- organelle membrane
- autophagic vacuole membrane
- autophagic vacuole
- axoneme
- microtubule
Molecular Function
What the gene product does at the molecular level
- ceramide binding
- phosphatidylethanolamine binding
- protein binding
- ubiquitin protein ligase binding
- microtubule binding