SHB Gene Summary [Human]
Enables phosphotyrosine residue binding activity. Predicted to be involved in several processes, including angiogenesis; apoptotic process; and signal transduction. Predicted to act upstream of or within several processes, including hematopoietic stem cell proliferation; negative regulation of oocyte maturation; and positive regulation of immune response. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SHB |
| Official Name | SH2 domain containing adaptor protein B [Source:HGNC Symbol;Acc:HGNC:10838] |
| Ensembl ID | ENSG00000107338 |
| Bio databases IDs | |
| Aliases | SH2 domain containing adaptor protein B |
| Synonyms | bA3J10.2, LOC158230, RGD1565350, SH2 domain containing adaptor protein B, Src homology 2 domain-containing transforming protein b |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SHB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor signaling complex scaffold protein
- Src homology 2 (SH2) domain
- phosphotyrosine binding
- protein binding
- proline rich domain
Pathways
Biological processes and signaling networks where the SHB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic sclerosis
- male pattern hair loss
- non-insulin-dependent diabetes mellitus
- idiopathic scoliosis
- bleeding
- acne
role in cell
- phosphorylation in
- binding in
- proliferation
- differentiation
- mitogenesis in
- hematopoiesis
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SHB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of oocyte maturation
- signal transduction
- angiogenesis
- apoptotic process
- B cell proliferation
- hemopoietic stem cell proliferation
- positive regulation of mitotic cell cycle
- T cell receptor signaling pathway
- positive regulation of T-helper cell differentiation
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein binding
- receptor signaling complex scaffold activity