FRK Gene Summary [Human]
The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FRK |
| Official Name | fyn related Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:3955] |
| Ensembl ID | ENSG00000111816 |
| Bio databases IDs | |
| Aliases | fyn related Src family tyrosine kinase |
| Synonyms | BSK, BSK/IYK, fyn-related kinase, fyn-related Src family tyrosine kinase, GTK, PTK5, RAK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FRK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- Src homology 2 (SH2) domain
- non-membrane spanning protein tyrosine kinase
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- Tyrosine kinase, catalytic domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the FRK gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- hepatocellular carcinoma
- tumorigenesis
- metastatic gastrointestinal stromal tumor
- colorectal cancer
- metastatic progressive colorectal cancer
- advanced colon cancer
- gastroesophageal junction adenocarcinoma
- gastroesophageal junction carcinoma
- undifferentiated gastric carcinoma
role in cell
- expression in
- proliferation
- migration
- morphology
- invasion
- outgrowth
- colony formation by
- epithelial-mesenchymal transition
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- secretory granule lumen
- azurophil granule lumen
- Cytoplasm
- Extracellular Space
- cytosol
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FRK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- innate immune response
- cell differentiation
- transmembrane receptor protein tyrosine kinase signaling pathway
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- specific granule lumen
- cytosol
- extracellular region
- azurophil granule lumen
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- receptor binding