PLXNB3 Gene Summary [Human]
The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | PLXNB3 |
| Official Name | plexin B3 [Source:HGNC Symbol;Acc:HGNC:9105] |
| Ensembl ID | ENSG00000198753 |
| Bio databases IDs | |
| Aliases | plexin B3 |
| Synonyms | KIAA1206, PLEXB3, plexin B3, PLEXR, PLXN6, RGD1560615 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLXNB3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Plexin repeat
- IPT
- Plexin cytoplasmic RasGAP domain
- cell adhesion molecule binding
- protein domain specific binding
- protein binding
- TIG domain
- Ras GTPase Activating Domain
- semaphorin domain
- Plexin cytoplasmic RhoGTPase-binding domain
- TIG domain found in plexin
- IPT/TIG domain
- intracellular domain
- semaphorin receptor
- PDZ binding motif
- Sema domain
- transmembrane receptor
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the PLXNB3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLXNB3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- negative regulation of GTPase activity
- negative regulation of lamellipodium assembly
- positive chemotaxis
- negative regulation of cell adhesion
- nervous system development
- homophilic cell adhesion
- cell chemotaxis
- positive regulation of axonogenesis
- regulation of GTPase activity
- positive regulation of neuron projection development
- positive regulation of endothelial cell proliferation
- negative regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- semaphorin receptor complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- Rho GDP-dissociation inhibitor binding
- semaphorin receptor activity