NPM3 Gene Summary [Human]

The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq, Oct 2008]

Details

Type
Protein Coding
Official Symbol
NPM3
Official Name
nucleophosmin/nucleoplasmin 3 [Source:HGNC Symbol;Acc:HGNC:7931]
Ensembl ID
ENSG00000107833
Bio databases IDs NCBI: 10360 Ensembl: ENSG00000107833
Aliases nucleophosmin/nucleoplasmin 3
Synonyms Nub1, nucleophosmin/nucleoplasmin 3, nucleophosmin/nucleoplasmin, 3, nucleoplasmin 3, PORMIN, RGD1565542, TMEM123
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NPM3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Nucleoplasmin-like domain
  • protein binding

Pathways

Biological processes and signaling networks where the NPM3 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • metastasis
  • prostatic neoplasm
  • prostatic neoplasia
regulated by
role in cell
  • growth
  • invasion by
  • processing in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • actin cytoskeleton
  • cytosol
  • nucleoli

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human NPM3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • chromatin remodeling
  • rRNA transcription
  • rRNA processing

Cellular Component

Where in the cell the gene product is active
  • cytoplasm
  • actin cytoskeleton
  • cytosol
  • nucleolus
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • RNA binding
  • histone binding
  • chromatin binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.